Faculty Profiles

Jamal Ibdah, MD, PhD, AGAF

Director, Division of Gastroenterology and Hepatology
Professor of Medicine Gastroenterology
Professor of Medical Pharmacology and Physiology
Raymond E. and Vaona H. Peck Chair in Cancer Research
Senior Associate Dean and Director of the MU Institute for Clinical and Translational Science

Clinical Interests:

Dr. Ibdah’s primary clinical interests include hepatology, nonalcoholic fatty liver disease, and liver disease in pregnancy, as well as nutrition.

Research Interests:

Dr. Ibdah has many research interests, some of which include molecular biology of fatty acid oxidation, adult and pediatric fatty liver disease, and liver disease in pregnancy, the role of nutrition in liver disease, and nonalcoholic steatohepatitis.

Visit Dr. Ibdah's research lab.

Board Certification:

Internal Medicine (ABIM)
Gastroenterology (ABIM)

Medical School

University of Jordan
Amman, Jordan

PhD Biochemistry

Medical College of Pennsylvania
Philadelphia, PA

Residency

North Carolina Baptist Hospital (Wake Forest University)
Winston-Salem, NC

Fellowship

Washington University/Barnes-Jewish Hospital
St. Louis, MO

Honors & Awards:

Graduate School Scholarship Award, 1984-1987
North American Conference for Gastroenterology Fellows Award for an Outstanding Program Presentation, Tampa, Florida, March 1997
Medical Foundation Teaching Scholar Award, Wake Forest University, 1997-1998
Medical Foundation Teaching Scholar Award, Wake Forest University, 1998-1999
Outstanding Investigator in Clinical Sciences Award, Wake Forest University, 2000 "Who's Who in America", 58th edition of Marquis Who's Who, 2004
Raymond E. and Vaona H. Peck Endowed Chair in Gastroenterology, University of Missouri at Columbia, 2005

Selected Publications:

Ibdah JA, Bennett MJ, Rinaldo P, et al. A fetal fatty acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 1999; 340: 1723-1731.
Ibdah JA, Paul H, Zhao Y, et al. Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest 2001; 107: 1403-1409.
Yang Z, Yamada J, Zhao Y, Strauss AW, Ibdah JA. Prospective screening for mitochondrial trifunctional protein defects in pregnancies complicated by liver disease. JAMA 2002; 288; 2163-2166.
Blish KR, Ibdah JA. Maternal heterozygosity for mitochondrial trifunctional protein defect as a cause for liver disease in pregnancy. Med Hypotheses 2005; 64: 96-100.
Gilbert J, Ibdah JA. Intestinal pseudo-obstruction as a manifestation of impaired mitochondrial fatty acid oxidation. Med Hypotheses 2005; 64: 586-589.
Ibdah JA, Perlegas P, Zhao Y, et al. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology 2005; 128: 1381-1390
Abdeen, M.B., Showdhury, N.A., Hayden, M.R. and Ibdah, J.A. “Nonalcoholic Steatohepatitis and the cardiometabolic syndrome”. JCMS 1:36-40, 2006.
Mishra, G., Zhao, Y., Sweeney, J., Pineau, B., Case, D. Ho, C., Blackstock, W. Geisinger, K. Howerton, R., Levine, E., Shen, P., and Ibdah, J. “Assessment of telomerase activity in samples obtained from pancreatic lesions by endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is clinically useful”. Gastrointest. Endosc 63:648-54, 2006.
Yang Z, Lanatz PE, Ibdah JA. Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death. Pediatr Int 2007; 49: 883-7.
Yongzhong W, Rector RS, Ibdah JA. Nonalcoholic fatty liver disease and mitochondrial dysfunction. World J Gastroenterol 2008; 14:193-199.
Wei Y, Chen K, Whaley-Connell AT, Stump CS, Ibdah JA, Sowers JR. Skeletal muscle insulin resistance: Role of inflammatory cytokines and reactive oxygen species. Am J Physiol Regul Integr Comp Physiol (in press).
Rector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW, Ibdah JA. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Am J Physiol Gastrointest Liver Physiol (in press).