Faculty Profiles
Yongzhong Wei, M.D., Ph.D., M.Sc.
Assistant ProfessorResearch Interests:
Dr. Wei’s research focuses on the molecular mechanisms of Ang II-induced oxidative stress and inflammatory cytokines on insulin signaling pathway in heart, skeletal muscle, and liver. Current research projects include: 1) Molecular mechanisms of oxidative stress and inflammatory cytokines effects on insulin signaling transport in skeletal muscle and heart using transgenic rat (Ren-2, overexpress Ang II), myotubes and cardomyocytes as an experimental model system; 2) The role of ROS and inflammatory cytokines on development of steatosis in Ren-2 rats; 3) The role of oxidative stress and inflammatory cytokines in heart function in Ren-2 rat.
Medical School
Third Military Medical University
Chongqing, China
Doctor of Philosophy
Third Military Medical University
Chongqing, China
Master in Engineering
Third Military Medical University
Chongqing, China
Selected Publications:
- Wei Y., Sowers J.R., Nistala R., Gong H., Uptergrove G., Clark S.E. Szary N., Manrique C., Stump C.S. NADPH oxidase activation by angiotensin II impair insulin signaling in skeletal muscle cells. Journal of Biology Chemistry. 2006 Sept 17.
- Wei Y., Sowers J.R., Clark S.E., Ferrario C.M., Stump C.S. Angiotensin II-Induced insulin resistance in skeletal muscle by activation of nuclear factor κB via gp91phox-dependent NADPH oxidase activation. Will be submitted to Journal of Clinical Investigation.
- Wei Y., Stump C.S., Uptergrove G., Chen K., Hibib J., Clark S.E., Ferrario C.M., Sowers J.R. Angiotensin II-induced NADPH oxidase activation contribute to vascular inflammation, apoptosis and remodeling in hypertensive transgenic Ren-2 rats. Will be submitted to Circulation Research.
- Stump C.S., Wei Y., Habib J., Nistala R., Clark S.E., Lassegue B., Griendling K.K., Ferrario C., Sowers J.R. NADPH oxidase mediates angiotensin II induced oxidative stress and insulin resistance in skeletal muscle in Ren2 rat. Will be submitted to Journal of Clinical Investigation.
- Wei Y, Chen K, Sharp GC, Braley-Mullen H. Decreasing TNFα results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis. Journal of Leukocyte Biology. 2006; Oct 17.
- Chen K, Wei Y, Alter A, Sharp GC, Braley-Mullen H. Chemokine expression during development of fibrosis versus resolution in a murine model of granulomatous experimental autoimmune thyroiditis. Journal of Leukocyte Biology. 2005, 78: 716-724
- Chen K, Wei Y, Sharp GC, Braley-Mullen H. Balance of proliferation and cell death between thyrocytes and myofibroblasts regulates thyroid fibrosis in granulomatous experimental autoimmune thyroiditis (G-EAT). Journal of Leukocyte Biology. 2005; 77:166-72.
- Wei Y, Chen K, Sharp GC, Braley-Mullen H. Fas ligand is required for resolution of granulomatous experimental autoimmune thyroiditis. Journal of Immunology. 2004, 173(12):7615-21
