Pulmonary Research
1. Projects:
- On going: Tolerance and safety of direct targeted aerosol chemotherapy - Joan's Legacy: The Joan Scarangello Foundation to Conquer Lung Cancer
- On going: Effects of Racemic, Inhaled b2 Agonists on Airway Inflammation in an Experimental Model of Feline Asthma; Sepracor
- On going: Targeted Inhalational Delivery of Chemotherapy via the AeroProbe Intratracheal Catheter in Dogs; Trudell
- On going: Aerosol Therapies for Emphysema
- On going: Nebulizer studies
- Preliminary: Gold Nanoparticles for lung targeting & therapy in lung cancer with Dr. Katti
- Preliminary: PBEF siRNA and lung cancer with Dr. Ye
2. Grants/contracts submitted or awarded
- Pending: Genetic Regulation of Drug Activities in the Lung; Waldrep, Dhand, Hoffman, Perry, Caldwell; VA Merit Review
- Pending: Targeted chemotherapy of canine lung tumors with the intracorporeal nebulizing catheter; Selting, Waldrep, Reinero, Dhand, Henry, Essman, Shultz, & Branson; Morris Animal Foundation
- Pending: Mechanisms of anticancer drug resistance and DNA repair- NIH (Co-Investigator with Dr. Stephen Alexander of Biological Sciences, Missouri University).
- Pre-Proposal Submitted: Inhaled Adjuvant Chemotherapy to Prevent Pulmonary Metastatic Osteosarcoma in Dogs; Selting, Waldrep, et al; American Kennel Club
- Awarded Contract: Evaluation of the Medel AG-CLASSIC compressor and Medel Jet nebulizer with albuterol sulfate, budesonide, and cromolyn sodium for FDA registration.
- Representatives from Respironics Respiratory Drug Delivery (Kurt Nikander) will visit labs on April 23 to discuss ongoing and future projects.
3. Publications (include accepted and submitted papers)
- In press: Comparative analysis of methods to measure aerosols generated by a vibrating mesh nebulizer; Waldrep, Berlinski, & Dhand; J. Aerosol Medicine
- Review In press: Advanced Nebulizer Designs Employing Vibrating Mesh/Aperture Plate Technologies for Aerosol Generation. Waldrep & Dhand, Current Drug Delivery
- Submitted: Feasibility and safety of targeted cisplatin delivery to a select lung lobe in dogs via the AeroProbe® intracorporeal nebulization catheter (INC) Kim A. Selting1, J. Clifford Waldrep2,3, Carol Reinero1, Daniel Gustafson4, Emmanuelle Mercier2, Keith R. Branson1, Dae Young Kim5, Carolyn J. Henry1,6, Nellie Owen1, P. Jack Hoopes7, Richard Madsen8, Rajiv Dhand2,3
4. Abstracts or posters
- American Thoracic Society, May 2007
- 2 posters on AeroProbe Dog Study (Waldrep presenter)
- 1 poster on mouse model of emphysema (Andersen presenter)
- 1 poster on gene/chemotherapy therapy in NSCLC (Guntur presenter)
- 1 poster on racemic abuterol in cats (Dhand presenter)
- 1 poster on non-invasive ventilation (Mercier presenter)
- ISAM, Tours, France June 2007
- 2 posters on AeroProbe Dog Study (Dhand presenter)
